Funding for this research was provided by:
Leiden University Medical Center
Text and Data Mining valid from 2019-05-17
Accepted: 16 April 2019
First Online: 17 May 2019
Compliance with ethical standards
: C. Mancao and A. Kiialainen are fulltime employees and stock option holders of F. Hoffmann-La Roche Ltd. None of the other authors have disclosures to declare.
: The AVANT trial was carried out in accordance with the declaration of Helsinki. The protocol was approved by local ethical review committees. For the current study, archival material was used in an anonymized manner. Therefore, no additional informed consent was required.