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Article History

Received: 24 May 2024

Accepted: 3 July 2024

First Online: 27 July 2024

Declarations

:

: Marcus Maurer reports speaker and/or consultant and/or institutional research support from Allakos, Alexion, Alvotech, Almirall, Amgen, Aquestive, ArgenX, AstraZeneca, Celldex Therapeutics, Celltrion, Clinuvel Pharmaceuticals, Escient Pharmaceuticals, Evommune, Excellergy Therapeutics, GSK, Incyte, Jasper Therapeutics, Kashiv BioSciences, Kyowa Kirin, LEO Pharma, Lilly, Menarini, Mitsubishi Tanabe Pharma, Moxie Pharmaceutical, Noucor, Novartis, Orion Pharma, Resonance Medicine, Sanofi-Regeneron Pharmaceuticals Inc., Santa Ana Bio, Septerna, Servier, Third Harmonic Bio, ValenzaBio, Vitalli Bio, Yuhan Corporation, and Zura Bio. Thomas B. Casale reports research support from Aimmune Therapeutics, Alladapt Immunotherapeutics, Allergy Therapeutics, ARS Pharma, Genentech, NIH, PCORI, Pfizer, Regeneron Pharmaceuticals Inc., and Sanofi; is a consultant for Aimmune Therapeutics, ARS Pharma, AstraZeneca, Genentech, Novartis, and Regeneron Pharmaceuticals Inc.; is on the speakers bureau for Genentech and Sanofi; and is the chief medical advisor for Food Allergy Research & Education (FARE). Sarbjit S. Saini reports receiving grants and/or research/clinical trial support from Amgen, Allakos, Escient Pharmaceuticals, NIH, Novartis, Sanofi, Regeneron Pharmaceuticals Inc., and served as a consultant or on advisory boards for Allakos, Aquestive, Celltrion, Escient Pharmaceuticals, Innate Therapies, Granular Therapeutics, Novartis, Regeneron Pharmaceuticals Inc., and Sanofi. Moshe Ben-Shoshan is a consultant with Bausch Health, Medexus Pharmaceuticals, Miravo, Novartis, Sanofi, and Stallergenes Greer. Elizabeth Laws, Deborah Bauer, and Melanie Makhija are employees of Sanofi and may hold stock and/or stock options in the company. Jennifer Maloney and Allen Radin are employees and shareholders of Regeneron Pharmaceuticals Inc.

: This study was conducted in accordance with the Declaration of Helsinki, the International Conference on Harmonisation Good Clinical Practice guidelines, and applicable regulatory requirements. All patients or their parents/guardians provided written informed consent before participating in the trial. Pediatric patients provided assent according to the Ethics Committee (Institutional Review Board [IRB]/Independent Ethics Committee)-approved standard practice for pediatric patients at each participating center.