Document is current

Article History

Received: 4 November 2025

Accepted: 8 January 2026

First Online: 27 January 2026

Declarations

:

: We thank the company Peptech ® for generously providing the bioactive collagen peptides (Peptpure ® ) for this study. In addition, we state that Prof. Dr. Rodolfo P. Vieira has received consultation fees and Rosa Helena Ramos Paula-Vieira and Sandra Regina Dias a MSc fellowship from Peptech ® . Lastly, we clarify that Peptech ® had no role in the study design, analysis, interpretation, conclusions, and manuscript writing. Anamei Silva-Reis, Meiry Souza Moura-Maia, Nycole Vieira Ramos-Gomes, Kananda Jesus-Silva, Yasmim Rodrigues Oliveira-Leal, Laura Thaís Castro-Pimentel, Wany Soares Fagundes Carvalho, Flavia Melo, José Luis Rodrigues Martins, and André Luis Lacerda Bachi have nothing to disclose.

: This study was approved by the Ethics Committee of the Evangelical University of Goiás (UniEVANGÉLICA), registration no. 7.233.377, and conducted in accordance with the Declaration of Helsinki. It was retrospectively registered at ClinicalTrials.gov (NCT06971029) on 13 May 2025 ( ). The randomized controlled trial followed CONSORT guidelines to ensure transparency and rigor. All recommendations from the CONSORT 2025 statement were addressed, and a flow diagram depicting enrollment, allocation, follow-up, and analysis is shown in Fig.  . Additionally, we clarify that at the time of enrollment, collagen peptides were classified as food supplements under Brazilian regulatory standards, and prospective public registration was not mandatory. No modifications to the study design, primary outcomes, dosage, or statistical plan were made after participant inclusion, and data collection was completed prior to registration. Registration was performed later to ensure international transparency and conformity with CONSORT/ICMJE recommendations. Patients’ rights to privacy were strictly observed throughout the study. No identifying information, including names, initials, hospital numbers, or images, was published in any form. The authors ensured that all participants were informed about the extent of the data shared and the potential for public access to identifiable material. In addition, all patients provided verbal and signed informed consent to participate in the study.