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Article History

Received: 25 February 2026

Accepted: 7 April 2026

First Online: 25 April 2026

Declarations

:

: Authors Minyue Qi, Paula Pitta, Katrin Wegner, Boris Kristof, Julia Gallinger, Marc Winnefeld, Cassandra Falckenhayn, and Elke Grönniger were employed by the company Beiersdorf AG. Lilia Guadanhim, Cheri Frey, and Frank Lyko received consultation fees from Beiersdorf AG. Manuel Rodríguez-Paredes received speaker fees from Beiersdorf SA. The remaining authors Günter Raddatz, Yan Feng, and Rungsima Wanitphakdeedecha declare that the research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest.

: Both studies were conducted in accordance with ethics requirements. The pilot study was approved by the Ethics Committee of the Faculty of Medicine at the University of Heidelberg (ref. S-783/2024), and all participants provided written, informed consent. Specifically, consent was obtained for the storage and processing of biosamples at the German Cancer Research Center (DKFZ) and for the processing and use of data for biomedical research, including publication. The product-use study was conducted in accordance with the principles of the Declaration of Helsinki, applicable regulatory requirements, including Resolution CNS no. 466/12, and ICH E6: Good Clinical Practices and Document of the Americas. This study was approved by the Independent Ethics Committee (IEC) of Investiga-Institutos de Pesquisa, registered by the National Research Ethics Commission (CONEP) (CEP approval no. CAAE 90155525.9.0000.5599). All participants provided written, informed consent for the collection of clinical data, biological samples, and facial images, as well as consent for the publication of anonymized data and images in scientific media.