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Authors
Nakayama, Akiyoshi https://orcid.org/0000-0002-6654-0726
Hayano, Kimiko https://orcid.org/0009-0003-7166-7582
Ueno, Miki https://orcid.org/0009-0004-5424-9060
Miyoshi, Yuka https://orcid.org/0000-0003-3141-6650
Nakashima, Hiroshi https://orcid.org/0000-0001-9517-2080
Shimizu, Seiko https://orcid.org/0009-0000-4749-9011
Hashimoto, Itsumi https://orcid.org/0009-0006-1241-8713
Toba, Miho
Kikuchi, Rion
Takehana, Nana
Miura, Michiru
Kawamura, Yusuke https://orcid.org/0000-0001-5021-1613
Toyoda, Yu https://orcid.org/0000-0002-7411-0531
Mizuno, Tomoko https://orcid.org/0009-0009-4518-5487
Tanabe, Risa https://orcid.org/0000-0003-3006-4761
Hamada, Yoshinobu https://orcid.org/0000-0001-5846-0702
Tamura, Takashi
Kato, Yasufumi
Mitsuda, Yoko
Nakaoka, Hirofumi https://orcid.org/0000-0002-8454-1159
Yamamoto, Ken https://orcid.org/0000-0002-1531-9685
Tsunoda, Masashi https://orcid.org/0000-0003-2892-1859
Shinomiya, Nariyoshi https://orcid.org/0000-0003-1497-487X
Matsuo, Hirotaka https://orcid.org/0000-0003-4302-8719
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (20H00566)
Japan Society for the Promotion of Science (20K10522)
Japan Society for the Promotion of Science (21H03350)
Japan Society for the Promotion of Science (24K02695)
Japan Society for the Promotion of Science (24K22217)
Japan Society for the Promotion of Science (221S0002)
Japan Society for the Promotion of Science (16H06279)
Japan Society for the Promotion of Science (16H06277)
Japan Society for the Promotion of Science (22H04923)
Japan Society for the Promotion of Science (221S0001)
Ministry of Defense- Japan (Defense Medicine Basic Research Program)
Ministry of Defense- Japan (Defense Medicine Advanced Research Program)
Japanese Society of Gout and Uric & Nucleic Acids (Young Scientists)
Masato Kawano Memorial Public Interest Foundation for Promotion of Pediatrics
Suzuken Memorial Foundation
Gout and Uric Acid Foundation
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Article History
Received: 14 August 2025
Accepted: 12 October 2025
First Online: 26 December 2025
Declarations
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: The authors declare that they have no conflicts of interest.
: This study was approved by the National Defense Medical College’s institutional ethical committee and that of Nagoya University. All procedures were performed in accordance with the Declaration of Helsinki and its later amendments.
: Written informed consent was obtained from each subject participating in this study.
