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Authors
Zhu, Linwen
Li, Ni
Shi, Huoshun
Song, Jie
Fang, Zhongjie
Shen, Qinbo
Zhu, Xiuying
Dan, Yanggang
Shao, Guofeng
Sun, Lebo https://orcid.org/0000-0002-3229-4790
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Funding
Funding for this research was provided by:
National Natural Science Fund (82400440)
Ningbo Medical Treatment Center Li Huili Hospital “Huili Fund” (2022YB015)
Ningbo Top Medical and Health Research Program (2022030107)
Ningbo “Technology Innovation 2025” Major Special Project (2022Z150)
Ningbo Health Branding Subject Fund (PPXK2018-01)
Natural Science Foundation of Ningbo (2025J297)
Natural Science Foundation of Ningbo (2025J289)
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Article History
Received: 21 March 2025
Accepted: 1 December 2025
First Online: 15 December 2025
Declarations
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: The authors declare that they have no competing interests.
: This study was approved by the Human Research Ethics Committee at The Affiliated Lihuili Hospital of Ningbo University (title of the approved project: has_circ_0000437/let-7f-5p/IL-6 axis activates MAPK signaling pathway to promote valve fibrosis and inflammatory cytokine transformation in rheumatic heart valvular disease, approval number: KY2021PJ191; date of approval: Nov. 15, 2021) and was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all patients.
: Not applicable.
