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Article History

Received: 5 January 2023

Accepted: 30 March 2023

First Online: 5 May 2023

Funding

: This study was funded by Institut de Recherches Internationales Servier (IRIS), including time spent by the authors and contributors, database license, software license, article writing, and the journal’s rapid service fee.

: Medical writing support was provided by Katrin Spiegel (Springer Healthcare France) and editorial support was provided by Sarah Novack (Springer Healthcare France).

: Authors had full access to the data in the study and take full responsibility for the integrity and accuracy of the data. Concept and design was carried out by all authors. Acquisition, analysis, or interpretation of data was performed by all authors. Drafting of the manuscript was performed by all authors. Critical revision for intellectual content was performed by all authors. Statistical analysis was performed by Jade Vadel.

: Virginie Simon is an employee of Institut de Recherches Internationales Servier (IRIS). Jade Vadel’s affiliation changed from Institut de Recherches Internationales Servier (IRIS) to IQVIA during the completion of the manuscript.

: The study protocol was approved by the Independent Scientific Advisory Committee (ISAC) of the Medicines and Healthcare products Regulatory Agency in the UK. ISAC is a non-statutory expert advisory body providing scientific and ethic approval on research requests to access data provided by CPRD.

: Please contact the authors for further information. Datasets used for this study are propriety of the Medicines and Healthcare products Regulatory Agency (MHRA) and are not publicly available.