Meca-Lallana, José E.
Prieto González, José M.
Caminero Rodríguez, Ana B.
Olascoaga Urtaza, Javier
Alonso, Ana M.
Durán Ferreras, Eduardo
Espinosa, Raúl
Dotor, Julio
Romera, Mercedes
Ares Luque, Adrián
Pérez Ruiz, Domingo
Calles, Carmen
Hernández, Miguel A.
Hervás García, Miguel
Mendoza Rodríguez, Amelia
Berdei Montero, Yasmina
Téllez, Nieves
Herrera Varó, Nicolás
Sotoca, Javier
Presas-Rodríguez, Silvia
Querol Gutierrez, Luis A.
Hervás Pujol, Mariona
Batlle Nadal, Jordi
Martín Ozaeta, Gisela
Gubieras Lillo, Laura
Martínez Yélamos, Sergio
Ramió-Torrentà, Lluís
Mallada Frechin, Javier
Belenguer Benavides, Antonio
Gascón-Giménez, Francisco
Casanova, Bonaventura
Landete Pascual, Lamberto
Berenguer, Leticia
Navarro, Laura
Gómez Gutierrez, Montserrat
Durán, Carmen
Rodríguez Regal, Ana
Álvarez, Elena
García-Estévez, Daniel A.
López Real, Ana M.
Llaneza González, Miguel A.
Marzo Sola, María E.
Sánchez-Menoyo, José L.
Oterino, Agustín
Villaverde González, Ramón
Castillo-Triviño, Tamara
Álvarez de Arcaya, Amaya
Llarena, Cristina
Funding for this research was provided by:
Sanofi España
Article History
Received: 29 May 2023
Accepted: 3 October 2023
First Online: 20 October 2023
Declarations
:
: Jose E. Meca-Lallana declares consulting fees, honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, support for attending meetings, participation on advisory boards, and receipt of equipment, materials, drugs, medical writing, gifts or other services from Biogen, Sanofi, Novartis, Roche, Merck and BMS. José M. Prieto González declares consulting fees from Bayer, Biogen, Daiichi Sankyo, Genzyme Corporation, Janssen, Merck, Novartis, Sanofi, Sandoz Iberia, Teva, Roche, Almirall, Celgene; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Bayer, Biogen, Genzyme Corporation, Merck, Novartis, Sanofi, Teva, Roche and Almirall; participation on advisory boards from Bayer, Biogen, Genzyme Corporation, Merck, Novartis, Sanofi, Sandoz Ibérica, Teva, Roche, Almirall and Celgene; receipt of equipment, materials, drugs, medical writing, gifts or other services from Bayer, Biogen, Genzyme, Merck, Novartis, Sanofi and Teva. Ana B. Caminero Rodríguez declares consulting fees from Biogen, Merck Serono, Novartis, Roche, Sanofi and Teva; payment or honoraria for lectures, presentations and speakers bureaus from Almirall, Bayer, Biogen, BMS, Merck, Mylan Pharmaceuticals SL, Novartis, Roche, Sanofi, Teva; support for attending meetings from Almirall, Biogen, Merck, Novartis, Roche, Sanofi, Teva; participation on advisory boards from Biogen, Merck, Roche, Sanofi; receipt of equipment, materials, drugs, medical writing, gifts or other services from Almirall, Bayer, Biogen, Merck, Roche, Sanofi. Javier Olascoaga Urtaza declares grants or contracts from Sanofi and support for attending meetings and travel from Sanofi. Ana M. Alonso declares consulting fees from Novartis, Biogen, Sanofi and Janssen; payment for speaker from Biogen, Merck, Roche, Sanofi, Novartis, BMS, Almirall; support for attending meetings from Teva. Eduardo Durán Ferreras declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, for expert testimony and for participation on advisory boards from Biogen, Sanofi, Merck, Roche, Teva, Novartis, Almirall; support for attending meetings from Biogen, Sanofi, Roche, Merck, Novartis. Julio Dotor declares payment for speaker from Sanofi, Merck, Biogen, UCB, Zambón, Almirall; support for attending meetings from Merck; participation on advisory boards from Merck and Janssen. Mercedes Romera declares honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, support for attending meetings and participating on advisory boards from Sanofi, Biogen, Merck, Roche and Novartis. Adrián Ares Luque declares consulting fees from Biogen, Roche, Merck and Sanofi, payment or honoraria for lectures, presentations, and speakers bureaus from Biogen, Novartis, Sanofi, Merck, Roche and Teva, and support for attending meetings from Biogen and Sanofi. Carmen Calles declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events, payment for expert testimony, and support for attending meetings and participating on advisory boards from Teva, Merck, Sanofi, Roche, Bristol Myers, Novartis, Biogen. Miguel A. Hernández declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and support for attending meetings from Sanofi, Merck, Roche, Novartis and Genzyme. Miguel Hervás García declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi, Merck, Novartis and Roche; support for attending meetings and travel from Merck, Novartis and Roche; participation on an advisory board from Merck. Amelia Mendoza Rodríguez declares payment or honoraria for lectures, presentations, speakers bureaus from Sanofi, Merk and Roche; support for attending meetings from Teva and Sanofi. Yasmina Berdei Montero declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi, Roche and Biogen; support for attending meetings from Biogen; participation on advisory board from Sanofi. Nicolás Herrera Varó has changed his affiliation during the completion of the manuscript (new affiliation: Hospital Virgen de la Concha, Zamora, Spain). He declares consulting and conference fees, honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and support for attending meetings/travel from Roche, Merck and Genzyme; payment for expert testimony from Genzyme. Javier Sotoca has changed his affiliation during the completion of the manuscript (new affiliation: Hospital Universitari Vall d’Hebron; Barcelona, Spain). He declares consulting fees from Bayer; payments or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Merck, Sanofi, Biogen, Novartis, Roche, Almirall; payment for advisory boards from Roche and Sanofi; support for attending meetings from Roche, Biogen and Sanofi. Silvia Presas-Rodriguez declares honoraria for speakers bureaus from Biogen and Novartis, support for attending meetings from Biogen, Novartis and Roche. Luis A. Querol Gutierrez declares consulting fees from Grifols, Sanofi-Genzyme, Johnson & Johnson, Novartis, Annexon Pharmaceuticals, Takeda, Alexion, CSL Behring; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi-Genzyme, Biogen, Merck, Grifols, Roche, CSL Behring; participation on advisory boards from Roche, UCB and Grifols. Mariona Hervás Pujol declares honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Novartis; support for attending meetings from Sanofi; participation on advisory boards from Sanofi, Biogen, Almirall and Bayer. Gisela Martín Ozaeta declares payment for lectures and a chair from Biogen and Merck; support for attending meetings from Biogen. Sergio Martínez Yélamos declares grants or contracts from Novartis, Roche, Merck and Biogen; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Biogen, Roche and Novartis; support for attending meetings from Biogen, Roche, Novartis and Merck; participation on advisory board from Biogen and Novartis. Lluís Ramió-Torrentà declares consulting fees, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and support for attending meetings from Novartis, Roche, Merck, Sanofi, Biogen. Javier Mallada Frechin declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Novartis and Sanofi. Antonio Belenguer Benavides declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi, Biogen and Novartis; payment for expert testimony from Sanofi and Biogen; support for attending meetings from Sanofi; participation on advisory boards from Sanofi. Francisco Gascón-Giménez declares consulting fees, payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and support for attending meetings and travel from Teva, Biogen, Almirall, Merck, Sanofi, Novartis; participation on advisory boards from Sanofi and Novartis. He is a member of the Valencia Committee Multiple Sclerosis Treatment of the Sanitary Local Government of the Region of Valencia in Spain and coordinator of the Multiple Sclerosis Group of the Valencia Neurology Society, Spain. Bonaventura Casanova declares grants or contracts from BMS, Merck and Novartis; consulting fees from Novartis, Roche and BMS; support for attending meetings from Sanofi. Lamberto Landete Pascual declares honoraria for an advisory board, educational activities and attending meetings from Sanofi, Teva, Novartis, Biogen, Roche, Merck, Bayer, Almirall, BMS, Janssen. Laura Navarro declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi, Biogen, Merck and Roche. Montserrat Gómez Gutierrez declares honoraria for lectures and presentations from Novartis, Merck, Sanofi, Biogen, Bial and BMS; support for attending meetings from Bial, Merck and Sanofi; participation on advisory boards from Novartis. Ana Rodríguez Regal declares consulting fees and honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Merck, Sanofi, Novartis, Biogen and Roche; participation on advisory boards from Sanofi and Merck. Elena Álvarez declares consulting fees from Almirall, Bayer, Biogen, Novartis, Sanofi, Merck, Teva, Roche; payment or honoraria for payment or honoraria for lectures, presentations, and educational events from Almirall, Bayer, Biogen, Novartis, Sanofi, Merck, Teva and Roche; support for attending meetings and travel from Almirall, Biogen, Novartis, Sanofi, Merck, Teva, Roche; participation on advisory boards from Sanofi and Merck. Daniel A. García-Estévez declares payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi and Novartis; support for attending meetings from Novartis; participation on an advisory board from Biogen. Ana M. Lopez Real declares consulting fees from Biogen, Merck, Sanofi; payment or honoraria for lectures, presentations and speakers bureaus from Roche, Biogen, Novartis, Merck and Sanofi. Miguel A. Llaneza González has changed his affiliation during the completion of the manuscript (new affiliation: Hospital Universitario Central de Asturias, Spain). He declares grants or contracts from Sanofi, Roche, Biogen, Merck, BMS, Janssen, Teva, Novartis; consulting fees from Sanofi, Roche, Biogen, Novartis, Merck, BMS, Janssen, Teva; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Sanofi, Roche, Biogen, Novartis, Merck, BMS, Teva, Janssen; payment for expert testimony from Sanofi, Novartis, BMS, Merck, Teva, Janssen, Biogen and Roche; participation on Advisory Board from Sanofi, Biogen, Janssen, Roche, BMS, Merck, Novartis, Teva. José L. Sánchez Menoyo declares grants or contracts from MS Base and Roche; honoraria for speakers bureaus from Sanofi, Merck and Novartis; support for travel from Biogen; participation on advisory boards from Merck and Sanofi. Agustín Oterino has changed his affiliation during the completion of the manuscript (new affiliation: Hospital Universitario Central de Asturias, Spain). He declares grants or contracts from Sanofi, Novartis, Merck; honoraria for speakers bureaus from Sanofi, Teva, Merck, Novartis, Almirall, Biogen, payment for expert testimony from Sanofi, Teva, Merck, Novartis, Almirall, Biogen, support for attending meetings from Merck, Sanofi, and as expert from Sanofi. Ramón Villaverde González declares consulting fees from Merck; honoraria for lectures from Merck, Roche, Biogen, Novartis, Sanofi; support for travel from Biogen and Roche. Tamara Castillo-Triviño declares consulting fees from Biogen, Sanofi, Novartis and Merck; honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Biogen, BMS, Merck, Novartis, Roche, Sanofi, Teva; support for attending meetings from Biogen, Janssen, Merck, Novartis, Roche, Sanofi, Teva. Amaya Álvarez de Arcaya declares consulting fees from Sanofi and Merck; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Biogen, Sanofi, Merck and Roche; support for attending meetings from Roche and Sanofi. Cristina Llarena declares consulting fees from Almirall, Novartis, Biogen, Roche, Genzyme/Sanofi, Teva, Merck. Raúl Espinosa, Domingo Pérez Ruiz, Nieves Téllez, Jordi Batlle Nadal, Laura Gubieras Lillo, Leticia Berenguer, Carmen Durán and María E. Marzo Sola declare that they have no competing interests.
: The ethics committee “Corporació Sanitària Parc Taulí of Sabadell” (Barcelona, Spain; reference number 2015619) approved the protocol. The study was conducted in accordance with the Declaration of Helsinki and local regulations and all patients provided written informed consent.