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Authors
Chen, Xuanyu
Zhang, Lingyu
Li, Gaoming
Xu, Xu
Ma, Jinfu
Zhu, Haoxuan
Shi, Xiaolei
Yang, Shihai
Wang, Zhixi
Chen, Mingyang
Yang, Yihui
Fan, Yuhan
Wang, Binghan
Liu, Guojian
Li, Linyu
Tian, Zhenxuan
Chen, Boyu
Ding, Chawen
Yang, Dahong
Sun, Wenzhe
Wang, Lilan
Fan, Shitao
Yue, Chengsong
Yu, Nizhen
Yang, Jie
Li, Zhuang
Zi, Wenjie
Lin, Kunxin https://orcid.org/0000-0001-8826-0816
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Funding
Funding for this research was provided by:
National Science Fund for Distinguished Young Scholars of China (82425021)
Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0527905)
National Natural Science Foundation of China (82271349)
Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China (KFKT202506)
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Article History
Received: 19 January 2026
Accepted: 2 March 2026
First Online: 28 March 2026
Declarations
:
: Xuanyu Chen, Lingyu Zhang, Gaoming Li, Xu Xu, Jinfu Ma, Haoxuan Zhu, Xiaolei Shi, Shihai Yang, Zhixi Wang, Mingyang Chen, Yihui Yang, Yuhan Fan, Binghan Wang, Guojian Liu, Linyu Li, Zhenxuan Tian, Boyu Chen, Chawen Ding, Dahong Yang, Wenzhe Sun, Lilan Wang, Shitao Fan, Chengsong Yue, Nizhen Yu, Jie Yang, Zhuang Li, Wenjie Zi, and Kunxin Lin have nothing to disclose.
: Ethics approval for the MARVEL trial was obtained from the Medical and Ethical Committees of the Second Affiliated Hospital of the Army Medical University (No. 2021-yandi131-01) and all participating centers. Study procedures were conducted according to the principles outlined in the Declaration of Helsinki (1964) and its later amendments. Written informed consent was obtained from all patients or their legally authorized representatives. Consent for publication was obtained from all patients or their legally authorized representatives. This manuscript contains only anonymized data and no identifiable individual participant information.
