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A Multimodal Latent Severity Axis for Alzheimer’s Disease: Probabilistic PCA, Bayesian Trajectories, and Stage-Aware Timing Effects

Published Online: 2026-04-30

Published Print: 2026-08

Authors

Haji, Babak

Tahami Monfared, Amir Abbas https://orcid.org/0000-0003-4003-3192
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Funding

Funding for this research was provided by:

Eisai Incorporated
License Information

Text and Data Mining valid from 2026-04-30

Version of Record valid from 2026-04-30
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Article History

Received: 14 March 2026

Accepted: 14 April 2026

First Online: 30 April 2026

Declarations

Conflict of interest: Babak Haji is an employee of Eisai Inc. Amir Abbas Tahami Monfared is also an employee of Eisai Inc. and holds the position of Adjunct Professor in the Department of Epidemiology, Biostatistics, and Occupational Health at McGill University (Montreal, QC, Canada). Additionally, he serves as an Associate Editor for the Journal of Alzheimer's Disease , a voluntary position for which he receives no honoraria.

Ethical Approval: Informed consent was obtained from all participants enrolled in ADNI in accordance with its study protocols. The present study involved secondary analysis of de-identified data and did not include any new research conducted by the authors involving human participants or animals. The study was conducted in accordance with the ethical principles of the 1964 Declaration of Helsinki and its later amendments, or comparable ethical standards.

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