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Article History

Received: 18 January 2026

Accepted: 17 April 2026

First Online: 8 May 2026

Change Date: 30 May 2026

Change Type: Update

Change Details: The original online version of this article was revised due to incorrect authors affiliation. Now, the authors affiliation has been corrected.

Declarations

:

: Anat Galor—Alcon Bausch + Lomb, EyeCool (advisor), OKYO. Christopher Rapuano has nothing to disclose. Alice Epitropoulos has nothing to disclose. Jayne Weiss- Regeneron. Stephen Pflugfelder—Alcon, Dompe, Kala, Kowa, Unfold. Preeya Gupta—Azura, Alcon, Aldeyra, Abbvie, Bausch + Lomb, Dompe, HanAll Biopharma, Johnson & Johnson Vision, Kala, Mazado Inc, Nordic Pharma, Ocular Science, Oculis, Orasis, Sight Sciences, Science Based Health, Spyglass, Surface Ophthalmics, Tarsus, Tear Clear, Thea, Tissue Tech, Inc, Trukera, Viatris, Visionology, Vital Tears, Zeiss, EyeCool Therapeutics (advisor). Deepinder Dhaliwal—Staar Surgical, Scope Ophthalmics, Thea, Tarsus, Bausch and Lomb, Aurion, Epion, Lenz, CSI Dry Eye. Laura Periman—Alcon, Alderyra, Allergan/Abbvie, Amgen, Azura, Bausch + Lomb, Bruder, Dompe, Eyedetec, Kala, Lumenis, Mallinckrodt, Myze, Nordic Pharma, Novartis, Nusight Medical, Olympic Ophthalmics, Quench Method, Science Based Health, Scope, Sun, Tarrsus, Thea, Versea, Viatris, Visant. Bonnie Henderson—Eyecool Therapeutics (advisor). Thanh T. Nguyen has nothing to disclose. Chameen Samarawickrama has nothing to disclose. Helen Wu has nothing to disclose. Tomasz Stryjewski—EyeCool Therapeutics (advisor). James A. Stefater—EyeCool Therapeutics (advisor). Mark Hinds—Financial Support: Azura Ophthalmics, Alcon, Alexion Pharmaceuticals, Pelthos Therapeutics, Eli Lilly and Company, EyeCool Technologies, Iolyx Therapeutics, Kiora Pharmaceuticals, Lubris Biopharma, Novo Nordisk Pharmaceuticals, Stuart. Therapeutics, Tarvo Biotherapeutics, TheiaNova. Consultant/Contractor: Azura Ophthalmics, CooperVision, Eyecool Therapeutics, Kiora Pharmaceuticals, SynergEyes USA., Iolyx Therapeutics, Avant Insurance, Wotton Kearney, Remedy Medico-Legal. Pooja Bhindi has nothing to disclose. Cristos Ifantides—Abbvie, Alcon, Bausch + Lomb, EyeCool Therapeutics (advisor), JnJ, Tarsus Pharmaceuticals, Trefoil.

: This study adhered to the tenets of the Declaration of Helsinki and was approved by each study site’s ethics committee. Study participants provided written informed consent prior to initiating any study procedure. The study was approved by St. Vincent’s Hospital (Melbourne Australia) Human Research Ethics Committee (HREC) and registered with Clinical Trials.gov (NCT06479382).