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Article History

Accepted: 18 January 2023

First Online: 4 February 2023

Declarations

:

: No external funds were used in the conduct of this study.

: Hideyuki Takimura received lecture honoraria from Otsuka Pharmaceutical Co. and Novartis Pharma Co. Atsumasa Kurozumi, Rintaro Taniguchi, Ippei Tsuzuki, Emi Tajima, Yukihiro Yamaguchi, Mami Kawano, Yukako Takimura, Satoru Nishio, Masatsugu Nakano, and Reiko Tsukahara declare they have no potential conflicts of interest that might be relevant to this paper.

: This study was executed in compliance with the Declaration of Helsinki regarding investigations in human subjects, and the study protocol was approved by the Ethics Committee of the Tokyo General Hospital.

: Not applicable.

: Not applicable.

: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: HT and MN made substantial contributions to the study concept and design. Data collection was undertaken by HT, AK, and ET. YT and SN analyzed all data. MK approved the statistical analysis. RT, IT, YY and RT supervised the project and reviewed the manuscript. HT, AK, MN and RT prepared the manuscript. All authors approved the final version.