Dixon, Padraig http://orcid.org/0000-0001-5285-409X
Beaver, Kinta http://orcid.org/0000-0002-6552-2323
Williamson, Susan
Sutton, Chris
Martin-Hirsch, Pierre
Hollingworth, William
Funding for this research was provided by:
Research for Patient Benefit Programme (PB-PG-0610-22123)
Article History
First Online: 12 April 2018
Compliance with Ethical Standards
: All patients provided written consent before registration in the trial. Ethical approval was granted by the National Research Ethics Service (11/NW/0648) and approval from the Research & Development departments of all participating centres was obtained prior to recruitment.
: The study was funded by the National Institute of Health Research (NIHR) under the Research for Patient Benefit programme (Grant Reference: PB-PG-0610-22123) (UKCRN ID: 11016; ISRCTN: 75220876). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The funder had no role in study design, data collection, data analysis, data interpretation, or writing the report.
: PD is a member of the MRC Integrative Epidemiology Unit at the University of Bristol which is supported by the Medical Research Council and the University of Bristol (MC_UU_12013/1, MC_UU_12013/9). PD acknowledges support from a Medical Research Council Skills Development Fellowship (MR/P014259/1). PD, KB, SW, CS, PMH, and WH declare no competing interests.
: The research team will consider requests for sharing of patient level data. Consent for data sharing was not obtained but the presented data are anonymised and risk of identification is low. Requests should be made to Professor Kinta Beaver.