Wright, Stuart J. http://orcid.org/0000-0002-4064-7998
Gray, Ewan http://orcid.org/0000-0003-3840-5268
Rogers, Gabriel http://orcid.org/0000-0001-9339-7374
Donten, Anna http://orcid.org/0000-0002-4896-6002
Payne, Katherine http://orcid.org/0000-0002-3938-4350
Funding for this research was provided by:
Programme Grants for Applied Research (RP-PG-1214-20016)
Cancer Research UK (International Alliance for Cancer Early Detection)
Article History
Accepted: 30 April 2024
First Online: 16 May 2024
Declarations
:
: Financial support for this study was provided in part by a grant from the National Institute for Health Research Predicting Risk of Cancer at Screening (PROCAS) 2 Programme Grant (Ref: RP-PG-1214-20016) and by the International Alliance for Cancer Early Detection, an alliance between Cancer Research UK, the Canary Center at Stanford University, the University of Cambridge, Oregon Health & Science University (OHSU) Knight Cancer Institute, University College London and The University of Manchester. The funding agreements ensured the authors’ independence in designing the study, interpreting the data, writing and publishing the report.
: All authors meet International Committee of Medical Journal Editors (ICMJE) criteria for authorship. SW formulated the research question, updated the model parameters, ran analyses and led the writing of the manuscript. EG formulated the research question and contributed to writing the manuscript. GR completed the checklists and contributed to writing the manuscript. AD contributed to updating the model parameters and writing the manuscript. KP formulated the research question, provided advice on the design for the overall study, and produced a first draft of the manuscript. KP acts as guarantor for this work. This manuscript has been read and approved by all the authors.
: Ewan Gray is an employee of Grail LLC and has received consultancy fees from Dxcover Limited and Wobble Genomics Limited. All remaining authors have no conflicts of interest to declare.
: Ethical approval was not required for this study, which used existing published data and information.
: The R code for the decision-analytic model structure is publicly available in a GitHub repository: . The repository is also archived using Zenodo and can be accessed using the doi:.