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Authors
Curzen, Nick
Candolfi, Pascal https://orcid.org/0000-0001-6728-451X
MacCarthy, Philip
Lloyd, Clinton T.
Aetesam-Ur-Rahman, Muhammad
Bromilow, Tom
Sellitto, Valentina
Blackman, Daniel J.
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Funding
Funding for this research was provided by:
Edwards Lifesciences
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Article History
Received: 25 April 2025
Accepted: 12 October 2025
First Online: 7 November 2025
Declarations
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: Nick Curzen received research grants from Boston, HeartFlow, Haemonetics and Beckman Coulter; speaker fees/consultancy from Abbott, HeartFlow, Shockwave and Boston; and travel sponsorship from HeartFlow, Biosensors and Shockwave. Pascal Candolfi is an employee at Edwards Lifesciences, Nyon, Switzerland. Philip MacCarthy has no conflicts of interest that are directly relevant to the content of this article. Clinton T. Lloyd has been a speaker for Edwards Lifesciences. Muhammad Aetesam-Ur-Rahman has been a consultant and received speaker fees from Medtronic and SMT. Tom Bromilow has been a consultant for Edwards Lifesciences. Valentina Sellitto is an employee at Edwards Lifesciences, Milan, Italy. Daniel J. Blackman received an institutional research grant from Medtronic and is a consultant and speaker for Medtronic, Abbott Vascular, JenaValve and Edwards Lifesciences.
: Not applicable.
: Not applicable.
: Not applicable.
: Input parameters values used and data generated during this cost-utility study are wholly included within this article and the associated Electronic Supplementary Material.
: Input parameters values used and data generated during this cost-utility study are wholly included within this article and the associated Electronic Supplementary Material. The code was only used in the model to run a probabilistic and deterministic sensitivity analysis and so will not be made available.
: PC led the project and contributed to the methodology, data analysis and manuscript drafting, and serves as the guarantor, ensuring the integrity and accuracy of the work. VS assisted with model adaptation and manuscript drafting. TB adapted the model, ensured the use of the best methodology and provided a health economics opinion. PMC, DB, CL, MAR and NC provided expert clinical opinion and economic guidance, contributing to the interpretation of results and critical review of the manuscript. All authors reviewed and approved the final version.
