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Article History

Accepted: 23 February 2023

First Online: 4 April 2023

Declarations

:

: This work was funded by JSC “GENERIUM”.

: All authors are employees of JSC “GENERIUM”.

: The animal study-specific protocols were approved by the respective Institutional Animal Care and Use Committee. All procedures performed on live animals as part of this study by Covance Laboratories Limited (Harrogate, UK) are subject to the provisions of UK national law, in particular the Animals (Scientific Procedures) Act 1986. The study in mice was conducted by The Jackson Laboratories (Bar Harbor, USA) and complied with all applicable sections of the Guide for the Care and Use of Laboratory Animals from the National Research Council.

: Not applicable.

: Not applicable.

: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

: Not applicable.

: VDG: conceptualization, supervision, methodology, validation, investigation, writing: original draft, writing: review and editing, visualization, formal analysis. MAS: supervision, methodology, formal analysis. IVL: supervision, methodology, validation, investigation, writing: original draft, formal analysis. MBD: methodology, investigation. EVR: investigation, methodology, writing: review and editing, formal analysis. AVR: methodology, investigation, visualization. MSP: methodology, investigation, visualization. RRS: project administration, conceptualization, resources, writing: review and editing. All authors contributed to the preparation of this manuscript.