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Article History

Accepted: 3 February 2025

First Online: 25 February 2025

Declarations

:

: This study was funded by the Canadian Institutes of Health Research Project Grant (PJT-178132). Wei Zhang has received salary support through a Michael Smith Health Research BC Scholar Award (#18286). Sang-Cheol Bae is supported in part by the Basic Science Research Program, through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2021R1A6A1A03038899). The funders had no role in the study design, data collection, analysis, interpretation, or decision to publish.

: Wei Zhang is leading a project on an entirely different topic that is funded by a grant-in-aid from Pfizer Canada. The University of British Columbia is the grant recipient. All other authors have no competing interests to declare.

: Ethical approval was not required for this study of sales data and published literature.

: Not applicable.

: Not applicable.

: Data were obtained under license from IQVIA. The data cannot be publicly shared as per a signed agreement. Requests for data can be sent to IQVIA Canada. Published policy literature is cited within the article and can be identified in the reference list.

: The software application code is not publicly available. As the software application code used to analyze sales data references data obtained under license from IQVIA, limited code may be available upon reasonable request to the corresponding author.

: WZ, AHA, DG, and NB substantially contributed to the conception and design of the work. WZ, AHA, and S-CB substantially contributed to the acquisition of the data. DG, ACTT, and JB substantially contributed to the analysis of the data. All authors substantially contributed to the interpretation of the data. ACTT, JB, and WZ drafted the work. All authors reviewed and revised it critically for important intellectual content. All authors provided final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

: This article is based on internal analysis by the authors using IQVIA MIDAS quarterly sales data for 2012–2023, which were obtained under license from IQVIA and reflect estimates of marketplace activity. Copyright IQVIA. All rights reserved. The statements, findings, conclusions, views, and opinions contained and expressed herein are not necessarily those of IQVIA.