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Article History

Accepted: 24 February 2025

First Online: 18 March 2025

Declarations

:

: This study was funded by Capital’s Funds for Health Improvement and Research, 2022-2Z-4056. All authors had full access to all of the study data and took complete responsibility for the integrity of the data and accuracy of the data analysis.

: Zhe Shi, Ling Zhang, and Yaolin Wang are employees of R&D, InventisBio Co., Ltd. No potential confict of interest was reported by the other authors.

: This study protocol had been approved by the Beijing Hospital Ethics Committee (no.2021BJYYEC-244-01; approval date: 30 Sept 2021) and was conducted in accordance with the Declaration of Helsinki and International Council for Harmonisation (ICH) guidelines for Good Clinical Practice (GCP).

: All participants gave their written informed consent for participation in this study.

: The informed consent form included a disclaimer that data will be anonymized and published.

: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: Not applicable. This study did not involve the use of any specific software application or custom code for data analysis or experimental procedures. All statistical analyses were performed using standard commercial software packages with built-in functions and no custom coding was necessary.

: LY, ZS, LZ, YW, and AS contributed to the study design. XG, YL, and XH contributed to the data collection. ZS, LZ, and LY performed the statistical analyses and interpretation and drafted the manuscript. YW and AS revised the manuscript. All authors contributed to the critical revision of the manuscript and approved its final version. Financial support and study supervision were provided by ZS, LZ, and YW.