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Article History

Accepted: 2 April 2025

First Online: 17 May 2025

Declarations

:

: The study was funded by Incyte Biosciences Japan GK (Tokyo, Japan). The open access fee was funded by Incyte Corporation (Wilmington, DE, USA) and Syndax Pharmaceuticals (New York, NY, USA). Employees of Incyte Biosciences Japan GK and Incyte Corporation participated in study design, data collection, analysis, interpretation, and manuscript writing.

: M.H. is an employee of SOSEIKAI Hakata Clinic. K.K. and K.S. are employees of Incyte Biosciences Japan GK and shareholders of Incyte Corporation. Y.Y., H.L., and M.P. are employees and shareholders of Incyte Corporation.

: Incyte Corporation (Wilmington, DE, USA) is committed to data sharing that advances science and medicine while protecting patient privacy. Qualified external scientific researchers may request anonymized datasets owned by Incyte for the purpose of conducting legitimate scientific research. Researchers may request anonymized datasets from any interventional study (except phase 1 studies) for which the product and indication have been approved on or after 1 January 2020 in ≥ 1 major market (e.g., USA, EU, JPN). Data will be available for request after the primary publication or 2 years after the study has ended. Information on Incyte’s clinical trial data sharing policy and instructions for submitting clinical trial data requests are available at: .

: The study was conducted in accordance with the provisions of the 1964 Declaration of Helsinki, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Guideline for Good Clinical Practice, and other applicable local regulations. Study protocols were approved by the SOUSEIKAI Hakata Clinic Institutional Review Board (approval no. VV-TMF-228501) on 9 February 2023.

: Written informed consent/assent was provided by all participants prior to enrollment.

: Not applicable.

: Not applicable.

: All authors contributed to study conception and design, data collection, data analysis, manuscript preparation, and commented on previous versions of the manuscript. All authors read and approved the final version of the manuscript.