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Article History

Received: 16 December 2024

Accepted: 24 August 2025

First Online: 17 September 2025

Declarations

:

: All authors declare: no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work. Bin Wu is an Editorial Board member of Clinical Drug Investigation. Bin Wu was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. The authors declare no financial or non-financial competing interests with any pharmaceutical companies mentioned in this article.

: Not applicable.

: Not applicable.

: Not applicable.

: All data generated from the simulation model are made available in the article.

: Not applicable.

: BW conceived the study and are the guarantors. KJY, HF, and BW drafted the manuscript. MXY, YB, KJY, and YC collected and analyzed the data. BW revised and approved the final version of the manuscript. YC, WL, and HF participated in the data preparation and provided important comments on the manuscript. All authors read and approved the final manuscript and are accountable for all aspects of the work, including accuracy and integrity.