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Article History

Received: 10 February 2025

Accepted: 29 August 2025

First Online: 16 September 2025

Declarations

:

: M.H. Park is an employee of Hanmi Pharmaceutical Co, Ltd and provided statistical analysis execution under academic supervision. S.A. Bae, J.W. Roh and J.W. Son have no conflicts of interest. The academic authors (S.A. Bae and J.W. Roh) had unrestricted data access, made all scientific decisions and take full responsibility for data integrity and accuracy of the analysis. The decision to publish was made solely by the academic investigators.

: The datasets generated and/or analysed during the current study are not publicly available owing to institutional data sharing policies but are available from the corresponding author on reasonable request.

: This study was approved by the Ethics Committee of Public Institutional Review Board, South Korea (registration no. P01-202111-21-018, date of approval: 25 November 2021). The study was conducted in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participants before enrolment.

: Informed consent was obtained from all patients included in the study.

: Data and code are available on reasonable request.

: Conceptualisation: J.W.R. and S.A.B. Data curation: M.H.P. Methodology: S.A.B. and J.W.R. Investigation: J.W.R. and J.W.S. Formal analysis: M.H.P. and S.A.B. Writing – original draft: S.A.B. and J.W.R. Writing – review and editing: all authors. Funding acquisition: S.A.B. Resources: M.H.P. Supervision: S.A.B. All authors read and approved the final version of the manuscript and agree to be accountable for all aspects of the work.