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Authors
Hong, Qianqian
Jiao, Yuhuan
Li, Dongyang
Ma, Hongyun
Wu, Kun
Xie, Liangzhi https://orcid.org/0000-0001-6765-6651
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Funding
Funding for this research was provided by:
National Major Science and Technology Projects of China (2018ZX09736002)
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Article History
Received: 18 June 2025
Accepted: 7 December 2025
First Online: 6 January 2026
Declarations
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: Qianqian Hong, Yuhuan Jiao, Dongyang Li, Hongyun Ma, Kun Wu, and Liangzhi Xie are employees of Sinocelltech Co., Ltd. and have stock ownership and/or potential stock option interests in the company. All authors have no conflicts of interest that are directly relevant to content of this article.
: The trial was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine (SCT510NSCLC01, approval no. 2017-EC-244) and Jilin Province Cancer Hospital Institutional Review Board (SCT510-A301, approval no. 201810-070-01).
: Patients provided written informed consent prior to trial enrollment.
: Not applicable.
: The data presented in this study are available on request from the corresponding author because of patient confidentiality.
: The NONMEM control streams for the final PopPK model and its associated output is provided in the ESM.
: All authors contributed to the study conception and design. Data curation and analysis were performed by QQH and YHJ. The first draft was developed by QQH. All authors have read and agreed to the published version of the manuscript.
