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Article History

First Online: 15 January 2018

Compliance with Ethical Standards

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: AbbVie funded the study, and contributed to its design, analysis and interpretation of the data, and to the writing, review and approval of the article.

: Drs. Minocha, Zeng, Medema and Othman are employees and shareholders of AbbVie. The authors declare no other relationships or activities that could appear to have influenced the submitted work.

: This study was conducted in accordance with the ICH guidelines, applicable regulations and guidelines governing clinical study conduct, and ethical principles as defined in the Declaration of Helsinki. The study protocols were approved by the Institutional Review Boards or Ethics Committees of the study sites.

: Informed consent was obtained from all individual participants included in the study.