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Article History

First Online: 7 August 2018

Compliance with Ethical Standards

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: The data that support the findings of this study are available from the corresponding author upon reasonable request.

: This study was funded by Novartis Pharma AG, Basel, Switzerland.

: Anne Gardin, Eric Legangneux, Yi Jin, Parasar Pal, Wenkui Li, and Kasra Shakeri-Nejad are employees of Novartis. Mike Ufer, Gianluca Rossato, Zhenzhong Su were employees of Novartis at the time of the conduct of this reasearch. They have no other potential conflicts of interest that might be relevant to the content of this manuscript.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.