Zwart, Tom C. http://orcid.org/0000-0003-3692-0901
de Vries, Aiko P. J.
Engbers, Aline G. J.
Dam, Ruth E.
van der Boog, Paul J. M.
Swen, Jesse J.
Keizer, Ron J.
Dalton, R. Neil
Guchelaar, Henk-Jan
de Fijter, Johan W.
Moes, Dirk Jan A. R.
Article History
Accepted: 3 February 2021
First Online: 17 April 2021
Declarations
:
: No funding was received for the preparation of this article.
: Ron Keizer is an employee and stockholder of InsightRX. Tom Zwart, Aiko de Vries, Aline Engbers, Ruth Dam, Paul van der Boog, Jesse Swen, Neil Dalton, Henk-Jan Guchelaar, Johan de Fijter and Dirk Jan Moes have no conflicts of interest that are directly relevant to the content of this article.
: All data for this study originated from participants from studies with previous medical ethical approval or were collected retrospectively from routine clinical care. Hence, this study by Dutch Law is considered research not subjected to the Medical Research Involving Human Subjects Act. A statement of non-objection was issued by the scientific committee of the Department of Internal Medicine of LUMC (W2019.033).
: All routinely screened donor candidates gave written informed consent for retrospective collection of their relevant medical records, in accordance with the European General Data Protection Regulation (Regulation [EU] 2016/679). The Scientific Committee of the Department of Internal Medicine of LUMC determined that participants from studies with previous medical ethical did not need to give additional written informed consent for retrospective use of their data for this study.
: Not applicable.
: The datasets generated during and/or analysed during this study are available from the corresponding author upon reasonable request.
: The NONMEM code used to generate and/or analyse the data described in this study is provided in the ESM.
: TCZ, APJdV, H-JG, JWdF and DJARM contributed to the study conception and design. TCZ and DJARM performed the research and analysed the data. RND and REvD contributed data. RJK contributed analytical tools. The initial draft of the manuscript was written by TCZ, APJdV and DJARM and all authors commented on previous versions of the manuscript. All authors read and approved the final version of the manuscript.