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Article History

Accepted: 28 April 2021

First Online: 27 May 2021

Declarations

:

: This work was funded by National Science and Technology Major Projects for ‘Major New Drugs Innovation and Development’ (2017ZX09304029-001, 2017ZX09304029-002), Young Taishan Scholars Program of Shandong Province, Qilu Young Scholars Program of Shandong University and Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University (FCYY201715), and the National Natural Science Foundation of China (Grant 81803433).

: Bo-Hao Tang, Zheng Guan, Karel Allegaert, Yue-E Wu, Efthymios Manolis, Stephanie Leroux, Bu-Fan Yao, Hai-Yan Shi, Xiao Li, Xin Huang, Wen-Qi Wang, A-Dong Shen, Xiao-Ling Wang, Tian-You Wang, Chen Kou, Hai-Yan Xu, Yue Zhou, Yi Zheng, Guo-Xiang Hao, Bao-Ping Xu, Alison H. Thomson, Edmund V. Capparelli, Valerie Biran, Nicolas Simon, Bernd Meibohm, Yoke-Lin Lo, Remedios Marques, Jose-Esteban Peris, Irja Lutsar, Jumpei Saito, Jacobus Burggraaf, Evelyne Jacqz-Aigrain, John van den Anker and Wei Zhao declare they have no potential conflicts of interest that might be relevant to the contents of this manuscript.

: All data were obtained from previous studies and these studies were approved by the institutional Ethics Committee.

: All the data were obtained from previous studies. All participants received written informed consent.

: Not applicable.

: Research data are not shared.

: Research code available.

: Bo-Hao Tang and Zheng Guan contributed equally to the interpretation of the data for this work, drafting of the initial manuscript, and revising the manuscript. Bo-Hao Tang, Yue-E Wu, Bu-Fan Yao, Hai-Yan Shi, Xiao Li, Xin Huang, Wen-Qi Wang, Yue Zhou, Yi Zheng, and Guo-Xiang Hao analysed the data. Zheng Guan, A-Dong Shen, Xiao-Ling Wang, Tian-You Wang, Chen Kou, Hai-Yan Xu and Bao-Ping Xu performed pharmacokinetic research. Karel Allegaert, Efthymios Manolis, Stephanie Leroux, Alison H. Thomson, Edmund V. Capparelli, Valerie Biran, Nicolas Simon, Bernd Meibohm, Yoke-Lin Lo, Remedios Marques, Jose-Esteban Peris, Irja Lutsar, Jumpei Saito, Jacobus Burggraaf, Evelyne Jacqz-Aigrain and John van den Anker provided advice and data sets, and critically reviewed and revised the manuscript. Wei Zhao designed the work, and critically reviewed and revised the manuscript.