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Article History

Accepted: 7 May 2023

First Online: 23 June 2023

Declarations

:

: JMJ, JGCH, DD, FA, KC, JHB, ADRH and TPCD wrote the manuscript; TPCD and ADRH designed the research; JMJ and DD performed the research; JMJ analysed the data.

: Open access funding provided by Uppsala University. Funding for the INCIP registry, sample bioanalysis and sample logistics was provided by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 647047), the Research Foundation-Flanders and the Belgian Cancer Plan, Ministry of Health, Belgium. Kristel Van Calsteren received a clinical research fund from the University Hospitals Leuven. Thomas P.C. Dorlo was personally supported by a Dutch Research Council (NWO)/ZonMw Veni grant.

: Frédéric C.H. Amant is a senior clinical investigator for the Research Fund-Flanders. All other authors declared no competing interests for this work.

: The data used in this study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by institutional review boards and independent ethics committees at participating 137 institutions.

: Informed consent was obtained from all individual participants included in the study.

: All individual participants signed informed consent regarding publishing their data.

: Not applicable.

: Not applicable.