Jansen, Anouk M. E. http://orcid.org/0000-0002-4736-6515
Mertens, Beatrijs http://orcid.org/0000-0002-1501-3045
Spriet, Isabel http://orcid.org/0000-0001-6342-0676
Verweij, Paul E. http://orcid.org/0000-0002-8600-9860
Schouten, Jeroen http://orcid.org/0000-0001-9118-4420
Wauters, Joost http://orcid.org/0000-0002-5983-3897
Debaveye, Yves http://orcid.org/0000-0003-1784-8297
ter Heine, Rob http://orcid.org/0000-0003-2185-8201
Brüggemann, Roger J. M. http://orcid.org/0000-0002-7618-725X
Clinical trials referenced in this document:
Documents that mention this clinical trial
Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies
https://doi.org/10.1007/s40262-023-01305-8
Article History
Accepted: 4 September 2023
First Online: 11 October 2023
Declarations
:
: Internal funds were provided by the Radboud University Medical Center.
: Joost Wauters received speakers’ fees, travel grants and investigator-initiated grants from Pfizer, MSD and Gilead, all outside the scope of this study. Paul E. Verweij reports grants or contracts from Gilead Sciences and F2G, and participation on a data safety monitoring board or advisory board for Pfizer, MundiPharma, Gilead Sciences and F2G, outside the submitted work. All payments were made to the institute. Roger J.M. Brüggemann has served as consultant to Astellas Pharma, Inc., F2G, Amplyx, Gilead Sciences, Merck Sharp & Dohme Corp., MundiPharma and Pfizer, Inc., and received unrestricted research grants from Astellas Pharma, Inc., Gilead Sciences, Merck Sharp & Dohme Corp. and Pfizer outside this study. All contracts and payments were through the institute. Yves Debaveye reports travel support from Pfizer; participation in advisory boards of Pfizer and MSD, outside the submitted work. Anouk M.E. Jansen, Beatrijs Mertens, Isabel Spriet, Jeroen Schouten and Rob Ter Heine have no conflicts of interest that are directly relevant to the content of this article.
: The study was approved by the Ethics Committees of the Radboud University Medical Center, the Netherlands (EC identifier: 2021-7327) and the University Hospitals Leuven, Belgium (EC identifier: S65556).
: Informed consent was obtained from all individual participants or their legal representatives.
: Not applicable.
: The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request and following legal approval. The final model control stream is available in the supplementary information.
: Not applicable.
: AJ, RB and RtH designed the study; AJ, BM, IS, JS, JW and YD performed the data collection; AJ performed the analysis with RB and RtH; AJ interpreted results with RB and RtH; AJ drafted the manuscript; and all authors critically reviewed the manuscript and approved the final version.