Kvitne, Kine Eide http://orcid.org/0000-0001-8118-7660
Hovd, Markus
Johnson, Line Kristin
Wegler, Christine
Karlsson, Cecilia
Artursson, Per
Andersson, Shalini
Sandbu, Rune
Hjelmesæth, Jøran
Skovlund, Eva
Jansson-Löfmark, Rasmus
Christensen, Hege
Åsberg, Anders
Robertsen, Ida
Funding for this research was provided by:
University of Oslo
Article History
Accepted: 8 October 2023
First Online: 22 November 2023
Declarations
:
: Open access funding provided by University of Oslo (incl Oslo University Hospital). Vestfold Hospital Trust, Norway, Department of Pharmacy, University of Oslo, Norway, and AstraZeneca, Sweden funded the preparation of this article.
: Cecilia Karlsson, Shalini Andersson, and Rasmus Jansson-Löfmark are AstraZeneca employees and own shares in AstraZeneca, while Christine Wegler is a former AstraZeneca employee. Kine Eide Kvitne, Markus Hovd, Line Kristin Johnson, Per Artursson, Rune Sandbu, Jøran Hjelmesæth, Eva Skovlund, Hege Christensen, Anders Åsberg, and Ida Robertsen have no conflicts of interest that are directly relevant to the content of this article.
: The COCKTAIL study was approved by the Regional Committee for Medical and Health Research Ethics (2013/2379/REK) and performed according to the Declaration of Helsinki.
: All patients gave written informed consent as part of the COCKTAIL study.
: Not applicable.
: Access to data collected from this study, including anonymized individual-participant data, may potentially be made available following publication upon request to the corresponding author. After approval of a proposal, data will be shared with investigators whose proposed use of the data has been approved by the COCKTAIL Steering Committee, according to the consent given by the participants and Norwegian laws and legislations.
: Not applicable.
: KEK drafted the manuscript. MH developed the population pharmacokinetic model. KEK, MH, and IR analyzed and interpreted the data. JH, AÅ, SA, CK, HC, ES, and RS designed the research. IR, LKJ, PA, CW, and RJ performed the research. All authors reviewed and approved the manuscript in its final version.