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Article History

Accepted: 9 August 2024

First Online: 7 September 2024

Declarations

:

: This study was sponsored by Novartis Pharmaceuticals.

: Francois Pierre Combes (FPC), Sherwin K. B. Sy (SS), Ying Fei Li (YFL), Kohinoor Dasgupta (KD), Sebastien Lorenzo (SL), Shruti Kapoor (SK), Matthias Hoch (MH), and Yu-Yun Ho (YYH) are employees of Novartis. FPC and MH are also Novartis stockholders. FPC is also a shareholder of Simulation Plus. None of the authors declares any other conflict of interest.

: Anonymized patient‐level data from clinical trials may be shared by Novartis in a consortium called ClinicalStudyDataRequest.com (CSDR) in accordance with Novartis’ policy for sharing clinical trial data ().

: Not applicable.

: Not applicable.

: This analysis was based on the data from patients enrolled in two different clinical trials. Both trials, serving as the data sources for this analysis, were approved by the appropriate Institutional Review Board.

: All the authors contributed to conception and design of the research, data collection, analysis, and interpretation, as well as drafting, reviewing, and providing final approval of the manuscript. Conceptualization: SS, FPC, MH, SL, YFL, YYH. Formal analysis: SS, FPC, SL, YFL. Validation: SS, FPC, SL, YFL. Investigation: SS, SL, FPC, YFL. Visualization: SL, FPC, YFL. Methodology: SS, SL, FPC, YFL, YYH. Writing—original draft: SS, SL, FPC, YFL. Writing—review and editing: SS, FPC, YFL, SL, MH, YYH, KD, SK.