Document is current

Article History

Accepted: 30 September 2024

First Online: 23 October 2024

Declarations

:

: Open Access funding provided by University of Turku (including Turku University Central Hospital). M.W.A. has received funding from University of Turku Graduate School and Finnish Cultural Foundation, Varsinais-Suomi Regional fund. This study was partially funded by state funding for university-level health research to Turku University Hospital (#11147 for M.W.A. and #13821 for T.I.S.) and to HUS Helsinki University Hospital (TYH2016239 for S.P., K.T.O. and V.K; TYH2019300 for J.B.; and TYH2019240 for M.N.), as well as the Sigrid Jusélius Foundation, Helsinki, Finland (M.N.).

: This study was a non-commercial, investigator-initiated trial and has not received any funding from the industry. The authors have no financial or proprietary interests in any material discussed in this article.

: The study protocol was reviewed and approved by approved by the Coordinating Ethics Committee of the Helsinki and Uusimaa Hospital District (3/2016) and the Finnish National Agency for Medicines (KL no. 4/2016).

: All participants provided written informed consent before study participation.

: All authors approved this manuscript for publication.

: Patient-level data for data on file in this manuscript are not available for sharing as there is a reasonable likelihood that individual patients could be re-identified. Further information can be requested from the authors.

: S.P., K.T.O. and V.K. conceived the idea and designed the study, contributed to the interpretation of the manuscript and gave final approval of the version to be published; M.Ne, J.I.K, J.B. and M.Ni. contributed to data analyses, interpretation of the manuscript and gave final approval of the version to be published; M.W.A. and T.I.S. supported in study design, collected model information and performed simulations and wrote and finalised the manuscript.