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Authors
Saleh, Ayatallah https://orcid.org/0000-0002-8161-9854
Schulz, Josefine https://orcid.org/0000-0002-0968-5873
Schlender, Jan-Frederik
Aulin, Linda B. S. https://orcid.org/0000-0003-4840-5704
Konrad, Amrei-Pauline https://orcid.org/0009-0001-2692-7061
Kluwe, Franziska https://orcid.org/0000-0002-5985-9683
Mikus, Gerd https://orcid.org/0000-0003-1783-133X
Huisinga, Wilhelm https://orcid.org/0000-0002-5249-3914
Kloft, Charlotte https://orcid.org/0000-0001-9344-8514
Michelet, Robin https://orcid.org/0000-0002-5485-607X
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Funding
Funding for this research was provided by:
Freie Universität Berlin
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Article History
Accepted: 30 September 2024
First Online: 30 October 2024
Declarations
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: Open Access funding was enabled and organised by Projekt DEAL.
: Charlotte Kloft and Wilhelm Huisinga report grants from an industry consortium (AbbVie Deutschland GmbH & Co. K.G., AstraZeneca, Boehringer Ingelheim Pharma GmbH & Co. K.G., Grünenthal GmbH, F. Hoffmann-La Roche Ltd, Merck KGaA, Novo Nordisk A/S and Sanofi) for the graduate research training programme PharMetrX. In addition, Charlotte Kloft reports research grants from the Innovative Medicines Initiative-Joint Undertaking (‘DDMoRe’), from H2020-EU.3.1.3 (‘FAIR’), Diurnal Ltd and the Federal Ministry of Education and Research within the Joint Programming Initiative on Antimicrobial Resistance Initiative (‘JPIAMR’), all outside the submitted work. Ayatallah Saleh, Josefine Schulz, Jan-Frederik Schlender, Linda B.S. Aulin, Amrei-Pauline Konrad, Franziska Kluwe, Gerd Mikus, and Robin Michelet declare no competing interests that may be relevant to the contents of this work.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All trial protocols were approved by the responsible Ethics Committees and the respective competent authorities.
: Written informed consent was obtained from all individual study participants before inclusion. Written informed consent was obtained from all individual study participants before inclusion.
: The datasets generated and/or analysed during the current study are not publicly available as patients did not provide consent for sharing their data in a public database. The datasets are available from the corresponding author upon reasonable request.
: The PBPK model will be available on the AK-Kloft GitHub website and can be freely downloaded.
: Conceptualisation: AS, RM, CK. Clinical data collection: GM, CK. In vitro data generation: JS, CK. Planning of analysis: AS, FK, RM, CK. Formal analysis and investigation: AS, RM, JFS, WH, GM, CK. Writing – original draft preparation: AS, RM. Writing – review and editing: All authors contributed to discussion of the results as well as reviewing and editing the manuscript.
