Document is current

Article History

Accepted: 7 November 2024

First Online: 25 December 2024

Declarations

:

: This study was supported by departmental funding and China Scholarship Council to Daming Kong (202006010035).

: Daming Kong, Jeffrey Lipman, Fabio Silvio Taccone, Michael Cohen-Wolkowiez, Fekade B. Sime, Danny Tsai, Pieter A. J. G. De Cock, Sutep Jaruratanasirikul, Sofie A. M. Dhaese, Andrew A. Udy, Robin Michelet, Céline Thibault, Jeroen V. Koomen, Douglas J. Eleveld, Michel M. R. F. Struys, Evelyn Dhont, Caroline Damen, Charlotte Kloft, Michael Zoller, Johannes Zander and Aziz Alobaid certify that they have no affiliations with or involvement in any organisation or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Over the last 3years Pieter J. Colin and his research group has been involved in contract research for PAION UK Ltd. (London, England) and Acacia Pharma Ltd. (Cambridge, England). Jason A. Roberts has received funding from the Australian National Health and Medical Research Council for a Centre of Research Excellence (APP2007007) and an Investigator Grant (APP2009736) as well as an Advancing Queensland Clinical Fellowship. Timothy W. Felton is supported by the NIHR Manchester Biomedical Research Centre (NIHR203308). Jan J. De Waele is supported by a Sr Clinical Research Grant from the Research Foundation Flanders (FWO, Ref. 1881020N). He has consulted for Menarini, MSD, Pfizer, ThermoFisher and Viatris (fees and honoraria paid to institution).

: Daming Kong, Pieter J. Colin, Douglas J. Eleveld and Jeroen V. Koomen contributed to the study conception and design. Data collection was performed by Jason A. Roberts, Jeffrey Lipman, Fabio Silvio Taccone, Michael Cohen-Wolkowiez, Fekade B. Sime, Danny Tsai, Pieter A. J. G. De Cock, Sutep Jaruratanasirikul, Sofie A. M. Dhaese, Andrew A. Udy, Timothy W. Felton, Robin Michelet, Céline Thibault, Julie Autmizguine and Pieter J. Colin. Data analysis was performed by Daming Kong. The first draft of the manuscript was written by Daming Kong and all authors reviewed and edited previous versions of the manuscript. All authors read and approved the final manuscript.

: Caroline Damen contributed to the literature search. Charlotte Kloft, Michael Zoller and Johannes Zander contributed to the planning and execution of some of the studies underlying the dataset. All collaborators contributed to collection and preprocessing of the data.

: Data will be made available upon reasonable request to the corresponding author and only if the authors of the original clinical trial agree with the transfer of the data.

: Institutional review board approval was attained for all original studies included in our analysis.

: Not applicable.

: Not applicable.

: The NONMEM code for the final PIP/TAZ population PK model is available in ESM3.