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Article History

Accepted: 16 March 2025

First Online: 19 April 2025

Declarations

:

: This study was funded by CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.

: Juan Wang, Tianhao Zhang, Lingli Yao, Huanhuan Qi, Xiaofang Zhang, and Rui Jia are employees of CSPC Pharmaceutical Group Co., Ltd. The other authors declare that they have no conflicts of interest.

: The data that support the findings of this study are available from the corresponding authors upon reasonable request.

: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee for Clinical Trials of Beijing Anzhen Hospital, Capital Medical University, and the Ethics Committee of The First Affiliated Hospital of Bengbu Medical University.

: Informed consent was obtained from all patients included in the study.

: Not applicable.

: Not applicable.

: Shan Jing, Xiaoli Li, and Tianhao Zhang conceptualized and designed the study; Lingli Yao, and Rui Jia provided administrative support; Juan Wang and Tianhao Zhang supplied study materials; Wenfang Liu, Kexu Yang, Yang Lin, Chunyan Lu, Jingyi Liu, and Huan Zhou performed data collection; Shan Jing, Wenfang Liu, Kexu Yang, Huanhuan Qi, and Xiaofang Zhang analyzed and interpreted the data; Shan Jing, Wenfang Liu, and Kexu Yang drafted the manuscript; all authors approved the final version; and Shan Jing and Xiaoli Li are accountable for all aspects of the work.