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Authors
Heddema, Wietske A.
Hof, Marieke A. J.
Sosnowski, Piotr
Bakker, Stephan J. L.
Hopfgartner, Gérard
Klont, Frank https://orcid.org/0000-0003-3503-1694
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Annema, Coby
Bakker, Stephan J. L.
Berger, Stefan P.
Blokzijl, Hans
Bodewes, Frank A. J. A.
de Boer, Marieke T.
Damman, Kevin
de Borst, Martin H.
Diepstra, Arjan
Dijkstra, Gerard
Doorenbos, Caecilia S. E.
Douwes, Rianne M.
Eisenga, Michele F.
Erasmus, Michiel E.
Gan, C. Tji
Gomes, Antonio W. Neto
Hak, Eelko
Hepkema, Bouke G.
Jonker, Jip
Klont, Frank
Knobbe, Tim J.
Kremer, Daan
Leuvenink, Henri G. D.
Lexmond, Willem S.
de Meijer, Vincent E.
Niesters, Hubert G. M.
Nieuwenhuijs-Moeke, Gertrude J.
Joost van Pelt, L.
Pol, Robert A.
Posthumus, Anna M.
Ranchor, Adelita V.
Sanders, Jan Stephan F.
Siebelink, Marion J.
Slart, Riemer J. H. J. A.
Swarte, J. Casper
Touw, Daan J.
van den Heuvel, Marius C.
van Leer-Buter, Coretta
van Londen, Marco
te Velde Keyzer, Charlotte A.
Verschuuren, Erik A. M.
Vos, Michel J.
Weersma, Rinse K.
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Funding
Funding for this research was provided by:
Stichting voor de Technische Wetenschappen (Veni 19060)
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Article History
Accepted: 19 March 2025
First Online: 26 April 2025
Declarations
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: Frank Klont gratefully acknowledges the funding provided by the Netherlands Organisation for Scientific Research NWO (domain Applied and Engineering Sciences) under Veni grant agreement no. 19060. The funder had no role in the study design, data collection, analysis, reporting, or the decision to submit for publication. Furthermore, the generation of the TransplantLines Food and Nutrition Biobank and Cohort Study (TxL-FN), trial registration number NCT02811835, was funded by the Top Institute Food and Nutrition, grant number A-1003. Continuation of the TransplantLines Food and Nutrition Biobank and Cohort Study was supported by grants from Astellas BV and Chiesi Pharmaceuticals BV and co-financed by the Dutch Ministry of Economic Affairs and Climate Policy by means of the public–private partnership allowance made available by Top Sector Life Sciences & Health to stimulate public–private partnerships. The funders had no role in the study design, data collection, analysis, reporting, or decision to submit for publication.
: The authors have no financial or proprietary interests in any material discussed in this article.
: This study used existing data of KTRs and PLKD included in the TransplantLines Food and Nutrition Biobank and Cohort Study (NCT identifier NCT02811835), which was approved by the institutional review board of the University Medical Center Groningen (decision METc 2008/186) and adhered to the Declaration of Helsinki.
: All participants provided written informed consent before study participation.
: Not applicable.
: The pharmacometabolomic data used have been deposited in an open-access data repository, as can be found at: []. Patient-level data for data on file in this manuscript are not available for sharing as there is a reasonable likelihood that individual patients could be re-identified. Further information can be requested from the authors.
: W.A.H., M.A.J.H., P.S., S.J.L.B., G.H., and F.K. wrote the manuscript. F.K. designed the research. W.A.H., M.A.J.H., and F.K. performed the research. W.A.H. and F.K. analyzed the data. S.J.L.B. and G.H. contributed new reagents/analytical tools.
