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Article History

Accepted: 28 April 2025

First Online: 26 May 2025

Declarations

:

: The trials and this analysis were funded by Camurus AB. Pharmacokinetic analysis by Pharmetheus AB was funded by Camurus AB. Support for third-party writing assistance for this article, provided by Melanie Seaton, PhD, and James Evry, MSc, Costello Medical, UK, was funded by Camurus AB in accordance with Good Publication Practice (GPP3) guidelines ().

: Anna Hansson, Markus Johnsson and Fredrik Tiberg are current employees of Camurus AB. Anaïs Glatard and Lina Keutzer are employees of Pharmetheus, who were contracted to perform the analysis. Sofia Friberg-Hietala is an employee and co-owner of Pharmetheus.

: The authors will not make data collected for this analysis available to others.

: Ethics approval and informed consent of each trial participant were obtained before trial inclusion, as detailed previously in the primary publications from the three clinical trials or within the appropriate records on the EudraCT or ClinicalTrials.gov registries (registration numbers: 2020-002643-35, NCT04076462, NCT04125836). These three clinical trials, and the analysis detailed here, were/are being conducted in accordance with Good Clinical Practice Guidelines and the ethical principles as laid down in the 1964 Declaration of Helsinki.

: Oral and written informed consent to participate was obtained from all trial participants before enrolment in the trials.

: All the results presented in this article are in aggregate form, and no personally identifiable information was used for this analysis.

: Due to its proprietary nature, the authors will not make code available to others.

: Substantial contributions to analysis conception and design: AG, SFH, LK, AH, MJ and FT; substantial contributions to analysis and interpretation of the data: AG, SFH, LK, AH, MJ and FT; drafting the article or revising it critically for important intellectual content: AG, SFH, LK, AH, MJ and FT; final approval of the version of the article to be published: AG, SFH, LK, AH, MJ and FT.