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Authors
Zou, Yuanxi https://orcid.org/0000-0003-0547-390X
Nedelman, Jerry https://orcid.org/0000-0002-0205-522X
Karlsson, Mats O. https://orcid.org/0000-0003-1258-8297
Svensson, Elin M. https://orcid.org/0000-0002-0093-6445
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Funding
Funding for this research was provided by:
Department of Foreign Affairs and Trade, Australian Government
Bill and Melinda Gates Foundation (OPP1129600)
Foreign, Commonwealth and Development Office
Bundesministerium für Bildung und Forschung
Irish Aid
United States Agency for International Development
Open access funding provided by Uppsala University
Uppsala University
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Article History
Accepted: 9 June 2025
First Online: 30 June 2025
Declarations
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: Open access funding provided by Uppsala University. This work was supported by TB Alliance (Global Alliance for TB Drug Development) with funding from Australia’s Department of Foreign Affairs and Trade, the Gates Foundation [OPP1129600], the Foreign, Commonwealth and Development Office (United Kingdom), Germany’s Federal Ministry of Education and Research through KfW, Irish Aid, and the United States Agency for International Development. This work was supported in part by the Gates Foundation [OPP1129600]. The conclusions and opinions expressed in this work are those of the author(s) alone and shall not be attributed to the Foundation. Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. The computations were enabled by resources in projects [NAISS 2023/22-1058] and [NAISS 2024/22-1458] provided by the National Academic Infrastructure for Supercomputing in Sweden (NAISS) at Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX), funded by the Swedish Research Council through grant agreement no. 2022-06725.
: Elin M Svensson is an editorial board member of Clinical Pharmacokinetics and so was not involved in the selection of peer reviewers for the manuscript or any of the subsequent editorial decisions. Yuanxi Zou, Jerry Nedelman, and Mats O Karlsson have no competing interests to declare that are relevant to the content of this article.
: Not applicable.
: Not applicable.
: Not applicable.
: Not applicable.
: Code is provided upon request.
: JN conceived the concept underlying this new approach. All authors contributed to the design of the study. YZ performed the modelling and simulation with input and support from EMS, MOK, and JN.
