Document is current

Article History

Accepted: 10 July 2025

First Online: 3 August 2025

Change Date: 28 August 2025

Change Type: Update

Change Details: The original online version of this article was revised to correct Reference 2.

Declarations

:

: This study was funded by Insmed Incorporated (Bridgewater, NJ, USA).

: Michael Konstan reports consulting fees from Insmed Incorporated. James Tolle and Emily DiMango have nothing to disclose. Patrick Flume reports consulting fees and research support from Insmed Incorporated. Helen Usansky, Ariel Teper, Christina Ramirez, Jimmy Flarakos, Jessica Basso, Sherry Li, and Marcela Vergara are employees and shareholders in Insmed Incorporated.

: This study was conducted in accordance with the protocol and consensus ethical principles derived from international guidelines, including the Declaration of Helsinki, Council for International Organizations of Medical Sciences International Ethical Guidelines, applicable International Council for Harmonisation Good Clinical Practices Guidelines, and other applicable laws and regulations.

: Participants and/or their legally authorized representative were informed that their participation was voluntary. Participants or their legally authorized representative were required to sign a statement of informed consent that met the requirements of ICH E6 (R2) guideline for good clinical practice (GCP) and any additional elements required by local regulations.

: Not applicable.

: The datasets generated and/or analyzed during the current study are not publicly available owing to patient privacy.

: Helen Usansky, Ariel Teper, and Marcela Vergara contributed to the study conception and design. All authors contributed to data collection, analysis, and interpretation. All authors critically reviewed all manuscript drafts, approved the submitted version of the manuscript, and made the decision to submit the manuscript for publication.