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Article History

Received: 21 March 2025

Accepted: 24 August 2025

First Online: 18 September 2025

Declarations

:

: J.P., M.Å., J.M., and H.E. are employees of AstraZeneca and hold stock in the company.

: J.P. performed the analysis. All authors contributed to the interpretation of the data. All authors were responsible for drafting and reviewing the manuscript content and editorial decisions and approved the final version.

: Data underlying the findings described in this manuscript may be obtained in accordance with AstraZeneca’s data sharing policy described at .

: Not applicable.

: All studies were conducted in accordance with ethical principles that had their origin in the Declaration of Helsinki and were consistent with International Council for Harmonisation Good Clinical Practice and the AstraZeneca policy on Bioethics and Human Biological Samples. All participants signed the informed consent before study initiation.