Updates are available Correction dated 2026-01-06
Click to view Correction: https://doi.org/10.1007/s40262-025-01613-1
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Authors
Sinha, Jaydeep https://orcid.org/0000-0002-2110-3370
Zimmerman, Kanecia https://orcid.org/0000-0003-3748-6932
Balevic, Stephen J. https://orcid.org/0000-0002-4016-1680
Hornik, Chi https://orcid.org/0000-0002-7656-3657
Muller, William J. https://orcid.org/0000-0001-7690-0695
Rathore, Mobeen https://orcid.org/0000-0001-7416-9755
Meyer, Marisa https://orcid.org/0009-0005-8400-5187
Finkelstein, Yaron https://orcid.org/0000-0002-0947-3571
Al-Uzri, Amira https://orcid.org/0000-0001-6532-7117
Lakhotia, Arpita https://orcid.org/0000-0003-2948-4531
Goldstein, Stuart https://orcid.org/0000-0003-3711-8785
Chen, Jia-Yuh https://orcid.org/0000-0002-5736-5970
Anand, Ravinder https://orcid.org/0000-0001-8628-2130
Gonzalez, Daniel https://orcid.org/0000-0001-5522-5686
,
Benjamin, Daniel K.
Kennel, Phyllis
Alderman, Cheryl
Sund, Zoe
Opel, Kylie
Beci, Rose
Hornik, Chi Dang
Kearns, Gregory L.
Laughon, Matthew
Paul, Ian M.
Sullivan, Janice
Wade, Kelly
Delmore, Paula
West, Leanne
Payne, Elizabeth
Chen, Lily
Simone, Gina
O’Connor, Kathleen
Cermak, Jennifer
Taylor, Lawrence
Green, Thomas
Benjamin, Danny
Taylor-Zapata, Perdita
Wade, Kelly
Kearns, Greg
Paul, Ian
Autmizguine, Julie
Capparelli, Edmund
Greenberg, Rachel
Alderman, Cheryl
Green, Terren
John, Ramany
Muller, William
Yogev, Ram
Fearn, Laura
Taravath, Sasidharan
Blanks, Tiffony
Lapid, Arielle
Harward, Melissa
Baisden, Nicole
Clark, Kira
Craven, Sarah
Grzesek, Kimberly
Joshi, Charuta
Drake, Austin
Filar, Lauri
Sargent, Jennifer
Oldham, Michael
Burmester, Julie
Eubanks, Stephany
Simeon, Terri
Shiloh-Malawsky, Yael
Anderson, Christopher
Jolly, Mallory
Joshi, Shradhdha
Odero, Norbert
Taylor, Jennifer
Arnold, Susan
Harper, Caryn
Howard, Erica
Martinez, Maria
Myer, Deanna
Walker, Angela
DeGrauw, Ton
Benoit, Macarthur
Sims, Christopher
Muller, William
Yogev, Ram
Fearn, Laura
Traisman, Benjamin
Sroka, Pam
Nielsen, Carol
Watt, Kevin
Baisden, Nicole
Milleson, Christie
Wrenn, Samantha
Mahmoudi, Kathleen Thoma Saniyyah
Riaz, Amna
Borges, Alexandrea
James, Laura
Hansberry, Dawn
Hart, Michelle
Howard, Lee
Ann, D Pierce
Sullivan, Janice
Kernen, Karrie
Poff, Susan
Konow, Courtney
Brown, Kelli
Comings, Jen
Michael, Andrew
Perry, Jackie
Wiseheart, Michelle
Laughon, Matthew
Bernhardt, Janice
Mariconti, Ashley
Talbert, Jennifer
Stryjewski, Glenn
John, Ramany
Kowal, Karen
Klipner, Kimberly
Rumantir, Maggie
Bradley, Gary
Gerhardt, Bradley
Kirby, Cassie
DePaoli, Bradley
Arnold, Patricia
Terrell, Tara
Mottes, Theresa
Pohl, Daniela
McMilan, Hugh
Zemek, Roger
Lacaze, Thierry
Leradi, Sara
Tuttle, Angie
Murchison, Barbara
Patubo, Kyle
Swanson, Connie
Farrar, Carrie
Kuchler, Andrea
Stubbs, Jennifer
Clark, Kira
Craven, Sarah
Grzesek, Kimberly
Lattimore, Susan
Mourani, Peter
Goldenberg, Neil
Van, Kevin
Rutebemberwa, Alleluiah
Sierra, Yamila
Malone, Kathryn
Deschenes, Jendar
Steinbeiss, Matthew
Ralston, Kimberly
Hastenson, Gentle
DiDomenico, Domninic
Dix, Megan
Autmizguine, Julie
Litalien, Catherine
Lague, Vincent
Dumitrascu, Mariana
Desmarasis, Diane
Massicotte, Christine
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Funding
Funding for this research was provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HHSN275201000003I)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD096435)
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Article History
Received: 29 January 2025
Accepted: 5 September 2025
First Online: 17 November 2025
Change Date: 29 December 2025
Change Type: Update
Change Details: The original online version of this article was revised to correct Equation 10.
Change Date: 6 January 2026
Change Type: Correction
Change Details: A Correction to this paper has been published:
Change Details: https://doi.org/10.1007/s40262-025-01613-1
Declarations
:
: The authors have no relevant conflicts of interest to disclose.
: JS's affiliation reflects the institution with which he was associated at the time this work was performed. SB receives support from the NIH and the Childhood Arthritis and Rheumatology Research Alliance, has done consulting work for UCB and Rutgers University, and serves on an NIH Data and Safety Monitoring Board. DG receives support from the Eunice Kennedy Shriver NICHD (R01HD096435, R01HD102949, R01HD113201, and HHSN275201000003I) and other sponsors for drug development in adults and children ( ). DG is an Editorial Board member of Clinical Pharmacokinetics . DG was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.
: To help expand the knowledge base for pediatric medicine, the PTN is pleased to share data from its completed and published studies with interested investigators. For requests, please contact PTN-Program-Manager@dm.duke.edu.
: The AED01 study was approved by the Duke Health Institutional Review Board (IRB) under IRB number Pro0007092, and the POP01 study was approved under IRB number Pro00029638.
: Informed consent and assent, when applicable, were obtained from all participants enrolled in the studies that facilitated the collection of oxcarbazepine data.
: Not applicable.
: The NONMEM code for the final population PK model is provided in the electronic supplementary material (see ESM2).
: Participated in research design: JS, KZ, SB, and DG. Performed the research: JS, KZ, SB, CH, WM, MR, MM, YF, AA-U, AL, SG, J-YC, RA, and DG. Performed the data analysis: JS and DG. Wrote or contributed to the writing of the manuscript: JS, KZ, SB, CH, WM, MR, MM, YF, AA-U, AL, SG, J-YC, RA, and DG.
