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Authors
Stapf, Maximilian https://orcid.org/0009-0003-6551-6569
Straub, Anton https://orcid.org/0000-0002-9452-9380
Steinacker, Valentin https://orcid.org/0009-0002-1406-9714
Hartmann, Stefan
Scherf-Clavel, Oliver https://orcid.org/0000-0002-1967-9231
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Funding
Funding for this research was provided by:
Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg
Horphag Research Ltd.
Open Access funding enabled and organized by Projekt DEAL
Ludwig-Maximilians-Universität München
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Article History
Received: 16 December 2024
Accepted: 9 September 2025
First Online: 27 September 2025
Declarations
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: The authors have no competing interests to declare that are relevant to the content of this article.
: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University of Würzburg (protocol code 51/20-me and 143/20-me, 2020) for studies involving humans.
: All patients have provided written informed consent to publish this paper.
: Data will be made available upon reasonable and justified request.
: The PBPK model described in the following work will be made available open source on Open Systems Pharmacology GitHub (https://github.com/Open-Systems-Pharmacology).
: Conceptualization: Maximilian Stapf, Oliver Scherf-Clavel; Methodology: Maximilian Stapf; Investigation and data acquisition: Maximilian Stapf, Anton Straub, Valentin Steinacker, Stefan Hartmann; Formal analysis: Maximilian Stapf; Writing—original draft preparation: Maximilian Stapf; Writing—review and editing: Anton Straub, Valentin Steinacker, Stefan Hartmann, Oliver Scherf-Clavel; Funding acquisition: Oliver Scherf-Clavel; Resources: Anton Straub, Stefan Hartmann, Valentin Steinacker, Oliver Scherf-Clavel; Project administration: Stefan Hartmann, Oliver Scherf-Clavel; Supervision: Oliver Scherf-Clavel.
