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Article History

Received: 13 May 2025

Accepted: 14 November 2025

First Online: 5 January 2026

Declarations

:

: All authors are employees of Jiangsu Hengrui Pharmaceuticals and have no conflicts to declare.

: All studies included in this analysis were approved by appropriate ethics committees and were conducted in accordance with the principles of the Declaration of Helsinki and the International Council for Harmonisation Good Clinical Practice guidelines.

: Informed consent was obtained from all participants prior to study inclusion.

: Not applicable

: The data that support the findings of this study are not openly available owing to reasons of sensitivity but are available from the corresponding author upon reasonable request.

: Not available.

: D.T. analyzed the data and drafted the manuscript. X.G., X.Y., and H.C. designed and performed the research. X.L., X.Z., and D.C. collated the dataset. M.Z., Y.D., and C.S. reviewed the manuscript, S.F. critically revised the manuscript for important intellectual content. All authors read and approved the final manuscript.