Lensker, Phyllis https://orcid.org/0009-0005-8024-2839
Gottschalk, Andrea https://orcid.org/0000-0003-0378-9601
Zerjatke, Thomas https://orcid.org/0000-0002-2125-9084
Roeder, Ingo https://orcid.org/0000-0002-6741-0608
Fromm, Martin F. https://orcid.org/0000-0002-0334-7478
Dörje, Frank https://orcid.org/0000-0003-0227-9212
Suttorp, Meinolf https://orcid.org/0000-0002-9522-8838
Rauh, Manfred https://orcid.org/0000-0002-4852-7157
Glauche, Ingmar https://orcid.org/0000-0002-2524-1199
Metzler, Markus https://orcid.org/0000-0002-4523-1676
Funding for this research was provided by:
Elterninitiative krebskranker Kinder e.V.
Tigerauge: Initiative Kinderhospitz Nordbayern e.V.
Sonnenstrahl e.V. Dresden, Förderkreis für krebskranke Kinder und Jugendliche
Friedrich-Alexander-Universität Erlangen-Nürnberg
Article History
Received: 18 December 2025
Accepted: 7 April 2026
First Online: 19 May 2026
Declarations
:
: Financial interests: The author MFF has received consultancy fees and lecture fees from Boehringer Ingelheim. He has received third-party funds for research projects at his institution by Boehringer Ingelheim and Heidelberg Pharma Research GmbH. The author MM has received consultancy fees and research funding from Novartis, and consultancy fees from Bristol Myers Squibb (BMS). PL, AG, TZ, IR, FD, MS, MR, and IG have no relevant financial or non-financial interests to disclose. MFF and MM have no relevant non-financial interests to disclose.
: All authors contributed to the study conception and design. Material preparation, data collection, and analyses were performed by Phyllis Lensker, Andrea Gottschalk, and Markus Metzler. The first draft of the manuscript was written by Phyllis Lensker and Andrea Gottschalk, and all authors commented on this and the subsequent versions of the manuscript. All authors read and approved the final manuscript.
: The prospective CML-PAED-II study was conducted in accordance with the Declaration of Helsinki, approved by the institutional ethics boards (EK282 122006 and EK 236_18 B) and registered ad EUDRACT (2007-001339-69) and Clinical-Trials.gov (NCT00445822).
: Written informed consent was obtained from the children and/or their legal guardians.
: Consent for publication was not applicable for this study.
: The datasets used in this study are available from the corresponding author upon reasonable request.
: The R-code for the statistical analysis is available from the authors upon request.