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Authors
Adiwidjaja, Jeffry https://orcid.org/0000-0002-6781-2113
Boddy, Alan V. https://orcid.org/0000-0002-8920-9286
McLachlan, Andrew J. https://orcid.org/0000-0003-4674-0242
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Funding
Funding for this research was provided by:
The University of Sydney
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Article History
Received: 5 May 2026
Accepted: 17 August 2026
First Online: 30 September 2026
Declarations
Conflict of Interest: At the time of the study, J.A. is an employee of Simulations Plus, Inc. The other authors have no competing interests to declare.
Ethics Approval: Not applicable.
Consent to Participate: Not applicable.
Consent for Publication: Not applicable.
Data and Code Availability: No new or proprietary data were generated as part of this study. All analyses were conducted using physiologically based pharmacokinetic modelling informed by previously published clinical data. The PBPK model is available from the corresponding author upon reasonable request.
Author Contributions: J.A. designed the research, performed the simulations, analysed the data, contributed to the interpretation, and drafted the manuscript. A.V.B. and A.J.M. designed the research, contributed to the interpretation, and critically revised the manuscript.
