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Article History

Accepted: 4 November 2020

First Online: 5 December 2020

Declarations

:

: This study was funded by the ANSM (Agence National de Sécurité du Médicament). The “DUMP” is registered under reference EUPAS26319 and received an ENCePP Seal that recognizes studies following the ENCePP principles of standards, transparency, and independence.

: The authors declare no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work. Competing financial interests unrelated to the present work: Louise-Laure Mariani received research support grants from INSERM, JNLF, and The L’Oreal Foundation; received speech honoraria from CSL, Sanofi-Genzyme, Lundbeck, and Teva; was a consultant for Alzprotect, Bionure, and Digitsole; and received travel funding from the Movement Disorders Society, ANAINF, Merck, Merz, Medtronic, Teva, and AbbVie, outside the submitted work. Olivier Rascol served as a member of advisory boards for AbbVie, Adamas, Acorda, Addex, AlzProtect, Apopharma, Astrazeneca, Bial, Biogen, Britannia, Buckwang, Clevexel, INC Reasearch, Lundbeck, Lupin, Merck, MundiPharma, Neuratris, Neuroderm, Novartis, ONO Pharma, Orion Pharma, Osmotica, Oxford Biomedica, Parexel, Pfizer, Prexton Therapeutics, Quintiles, Sanofi, Servier, Sunovion, Théranexus, Takeda, Teva, UCB, Watermark, Research, XenoPort, XO, and Zambon and received a grant from Agence Nationale de la Recherche (ANR), CHU de Toulouse, France-Parkinson, INSERM-DHOS Recherche Clinique Translationnelle, MJFox Foundation, Programme Hospitalier de Recherche Clinique, and the European Commission (FP7, H2020) as well as a grant to participate in a symposium and contribute to the review of an article IPMDS, outside the submitted work. Jean-Denis Turc received an honorarium from Abbvie for a symposium outside the submitted work. Jean-Christophe Corvol served as a member of advisory boards for UCB, Biogen, Prevail Therapeutic, Idorsia, Sanofi, Ever Pharma, Denali, BrainEver, and Theranexus, and received an unrestricted grant from the Michael J. Fox Foundation outside the present work. Florence Tubach is head of the Centre de Pharmacoépidémiologie (Cephepi) of the Assistance Publique – Hôpitaux de Paris and of the Clinical Research Unit of Pitié-Salpêtrière Hospital, both these structures have received research funding, grants, and fees for consultant activities from a large number of pharmaceutical companies that have contributed indiscriminately to the salaries of its employees. Florence Tubach did not receive any personal remuneration from these companies.

: This is an observational study that did not involve any patients. All data were collected anonymously. In accordance with French law, no ethical approval is required.

: The datasets generated during and analyzed during the current study are available from the corresponding author on reasonable request.

: L-LM, OR, J-DT, ML-M, J-CC, and FT contributed to the study conception and design. Analyses were performed by HA and DL. The first draft of the manuscript was written by DL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.