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Article History

Accepted: 19 April 2025

First Online: 7 June 2025

Declarations

:

: The Ethics Committee for Northwest and Central Switzerland (project ID: 2020-00354) approved the study, which was performed in accordance with the Sixth Revision of the Declaration of Helsinki.

: This study was funded by the Swiss Federal Office of Public Health. The funding covered costs related to laboratory analyses, equipment and participant compensation. The funding source had no role in the design of the study, data collection, analysis, interpretation of the data, or the writing of the manuscript. Open access funding was provided by the University of Basel as part of an institutional agreement with Springer Nature. 

: The authors declare they have no conflict of interest.

: Written informed consent was obtained from all individual participants included in the study.

: Not applicable.

: The data that support the findings are available from the corresponding author upon reasonable request.

: Not applicable.

: A.G. and M.V. conceived the study. A.G., S.B.V., M.M., and B.K. carried out the clinical procedures and blood sampling. S.B.V., J.T., D.L., and U.D. were responsible for pharmacokinetic analyses. M.V., K.M.D., and M.E.L. supervised the project. M.V. was responsible for funding acquisition. A.G., J.N.W., and S.B.V. wrote the initial manuscript draft. All authors were involved in revising the manuscript. All authors have read and approved the final submitted manuscript and agree to be accountable for the work.