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Article History

Accepted: 19 May 2025

First Online: 15 June 2025

Declarations

:

: This work was funded by Xian Janssen Pharmaceutical Co., Ltd.

: Qian Li and Tianmei Si declare that they have no conflicts of interest. Yang Li, Chong Ye, and Miaomiao Jia are employees of Xian Janssen Pharmaceutical Co., Ltd, which is a subsidiary of Johnson & Johnson. Jianmin Zhuo is an employee of Johnson & Johnson (China) Investment Ltd. Yishen Yang is an employee of IQVIA, which was contracted by Johnson & Johnson for the presented analyses.

: Underlying data supporting this study are not publicly available due to ethical reasons.

: For each study (NCT01527305, NCT01947803, and NCT01685931), the protocols were reviewed and approved by the local study site’s institutional review board or by an independent ethics committee. The studies were conducted in accordance with the Declaration of Helsinki and Good Clinical Practice and any applicable local regulatory requirements.

: Written informed consent was obtained from the patients prior to entering the phase 4 studies.

: Not applicable.

: Not applicable.

: Qian Li, Yang Li, and Tianmei Si conceived the idea and design of the study. Yishen Yang and Jianmin Zhuo performed data collection, extraction, and analysis. Qian Li, Yang Li, Chong Ye, Jianmin Zhuo, Yishen Yang, and Miaomiao Jia drafted the paper. Tianmei Si provided clinical support for drafting the paper. All authors reviewed the final manuscript. All authors have read and approved the final submitted manuscript and agree to be accountable for the work.