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Article History

First Online: 30 September 2016

Compliance with Ethical Standards

: The manuscript complies with ethical standards; it has been approved by the ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

: No sources of funding were used to assist in the preparation of this study.

: Francesco Patti has served on the scientific advisory board for Teva, Biogen-Idec, Bayer-Schering, Novartis, and has received honoraria as a speaker for Teva, Biogen, Merck-Serono, Bayer-Schering, Genzyme/Sanofi, and Novartis. Hayrettin Tumani serves on a scientific advisory board, as a consultant for, and/or received funding for research projects and travel from Bayer, Biogen, Genzyme, Merck-Serono, Novartis, Roche, Siemens, and Teva; serves on editorial board for MSI (Multiple Sclerosis International) and NPBR (Neurology, Psychiatry and Brain Research); and receives research support from BMBF, University of Ulm, Landesstiftung BW. Emanuele D’Amico, Carmela Leone, and Aurora Zanghì have no conficts of interest that are directly relevant to the content of this study.

: Emanuele D’Amico contributed to conception and design. He participated in drafting and revising the article. Hayrettin Tumani and Aurora Zanghì contributed to the draft and revising the article; Francesco Patti contributed in revising the article. He gave final approval of the version to be submitted and any revised version.