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Article History

Accepted: 8 December 2021

First Online: 22 January 2022

Declarations

:

: No sources of funding were used to assist in the preparation of this article.

: All authors have completed the ICMJE uniform disclosure form. JKA and REF have both written widely about adverse drug reactions and interactions and have from time to time received fees for legal reports, payments for articles, and royalties on books that they have written on the subject. The West Midlands Centre for Adverse Drug Reactions is associated with the Yellow Card Centre West Midlands, which receives funds from the MHRA. CA has no other conflicts of interest relevant to this article. RS is a member of the Central Advisory Committee, and an Electronic Review Committee, which advise the MHRA on governance of the Clinical Practice Research Datalink; the views expressed here do not reflect that role or that of the MHRA. All authors assert that the views expressed in this article are their own and do not necessarily reflect those of any organization with which they may be associated.

: Not applicable.

: Not applicable.

: Not applicable.

: Publicly available data were used for this research.

: Not applicable.

: All authors contributed to the design of the study and the analysis of the results. CA and REF retrieved the data for the study. REF wrote the first draft of the manuscript. RS constructed the graphs. All authors contributed to manuscript revision and read and approved the submitted version.

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