Martin, Guillaume L.
Jouganous, Julien
Savidan, Romain
Bellec, Axel
Goehrs, Clément
Benkebil, Mehdi
Miremont, Ghada
Micallef, Joëlle
Salvo, Francesco
Pariente, Antoine
Létinier, Louis http://orcid.org/0000-0001-5082-4866
,
Funding for this research was provided by:
Agence Nationale de Sécurité du Médicament et des Produits de Santé
Article History
Accepted: 9 February 2022
First Online: 17 May 2022
Declarations
:
: Public funding was received by Synapse Medicine for this work, following a contract with the French Agency for the Safety of Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé).
: Guillaume Louis Martin, Julien Jouganous, Axel Bellec, Romain Savidan, Clément Goehrs and Louis Létinier were employed by Synapse Medicine at the time this research was conducted or hold stock/stock options therein. All other authors declared no competing interests.
: This study and the use of the French pharmacovigilance database have been validated by the French Agency for the Safety of Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé). The data studied are the property of the Agence Nationale de Sécurité du Médicament et des Produits de Santé. Storage of the data is managed by service providers certified as “Hébergeur de Données de Santé” (Health Data Host).
: This study and the use of the French pharmacovigilance database have been validated by the French Agency for the Safety of Health Products (Agence Nationale de Sécurité du Médicament et des Produits de Santé).
: Not applicable.
: Data are not shareable as they are the property of the Agence Nationale de Sécurité du Médicament et des Produits de Santé.
: The example code in Python for the AI pipelines is provided on the following git repository: https://github.com/louisletinier/MAITAI. For more information about data management or our algorithms, please contact the corresponding author.
: G.L. Martin designed the research, analysed the data and wrote the manuscript. J. Jouganous, A. Bellec and R. Savidan designed the research, implemented models and critically reviewed the article. C. Goehrs critically reviewed the article. A. Pariente designed the research, critically reviewed the article, and was involved in the selection and acquisition of data. M. Benkebil, G. Miremont, J. Micallef and F. Salvo were involved in the selection and acquisition of data, and critically reviewed the article. L Létinier designed the research, analysed the data and critically reviewed the article. He is the guarantor; he had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. All authors read and approved the final version of the manuscript and agreed to its publication.
: We used the STARD 2015 reporting guidelines [], with its checklist available as Electronic Supplementary Material.